Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Rong Deng
LAB HEAD: Rong Deng
PROVIDER: PXD019946 | Pride | 2020-08-05
REPOSITORIES: Pride
Li Zhi-Ling ZL Zhang Hai-Liang HL Huang Yun Y Huang Jun-Hao JH Sun Peng P Zhou Ning-Ning NN Chen Yu-Hong YH Mai Jia J Wang Yan Y Yu Yan Y Zhou Li-Huan LH Li Xuan X Yang Dong D Peng Xiao-Dan XD Feng Gong-Kan GK Tang Jun J Zhu Xiao-Feng XF Deng Rong R
Nature communications 20200730 1
Most triple-negative breast cancer (TNBC) patients fail to respond to T cell-mediated immunotherapies. Unfortunately, the molecular determinants are still poorly understood. Breast cancer is the disease genetically linked to a deficiency in autophagy. Here, we show that autophagy defects in TNBC cells inhibit T cell-mediated tumour killing in vitro and in vivo. Mechanistically, we identify Tenascin-C as a candidate for autophagy deficiency-mediated immunosuppression, in which Tenascin-C is Lys63 ...[more]