Proteomics

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A proteomic map of resting and activated CD4+ T cells

ABSTRACT: CD4+ T cells (T helper cells) are cytokine-producing adaptive immune cells that activate or regulate the responses of different immune cells. They are known to play crucial roles in antibody class switching in B cells, neutrophil recruitment and activation of macrophages and CD8+ cytotoxic T cells. The activation and functional status of CD4+ T cells is important for adequate responses to pathogen infections but has also been associated with auto-immune disorders and survival in several cancers. In the current study, we carried out proteomic profiling of resting and activated primary human CD4+ T cells from healthy donors. In addition to identifying known markers of CD4+ T cell activation, we also identified protein kinases, protein phosphatases, and cytokines to be differentially expressed.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Primary Cell, T Cell

SUBMITTER: Richard K. Kandasamy  

LAB HEAD: Richard K. Kandasamy

PROVIDER: PXD021250 | Pride | 2023-01-18

REPOSITORIES: Pride

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CD4_T_activated_D1_SCX_1_R1.raw Raw
CD4_T_activated_D1_SCX_1_R2.raw Raw
CD4_T_activated_D1_SCX_1_R3.raw Raw
CD4_T_activated_D1_SCX_2_R1.raw Raw
CD4_T_activated_D1_SCX_2_R2.raw Raw
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Publications

The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function.

Subbannayya Yashwanth Y   Haug Markus M   Pinto Sneha M SM   Mohanty Varshasnata V   Meås Hany Zakaria HZ   Flo Trude Helen TH   Prasad T S Keshava TSK   Kandasamy Richard K RK  

International journal of molecular sciences 20201229 1

CD4+ T cells (T helper cells) are cytokine-producing adaptive immune cells that activate or regulate the responses of various immune cells. The activation and functional status of CD4+ T cells is important for adequate responses to pathogen infections but has also been associated with auto-immune disorders and survival in several cancers. In the current study, we carried out a label-free high-resolution FTMS-based proteomic profiling of resting and T cell receptor-activated (72 h) primary human  ...[more]

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