Proteomics

Dataset Information

0

Protective effects of breviscapine on HFHC diet-induced C57 mice


ABSTRACT: The proteomics data of liver tissue of 16-week-old HFHC-induced mice treated with saline or breviscapine for 8 weeks. The mice fed with high fat and high cholesterol were also divided into two groups. The control group was treated with normal saline for 8W, and the drug group was treated with breviscapine for 8W n=3.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Jiao Guo  

LAB HEAD: Jiao Guo

PROVIDER: PXD029867 | Pride | 2022-08-12

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
HFHC-16W-Breviscapine-8W-1.raw Raw
HFHC-16W-Breviscapine-8W-2.raw Raw
HFHC-16W-Breviscapine-8W-3.raw Raw
HFHC-16W-NS-8W-1.raw Raw
HFHC-16W-NS-8W-2.raw Raw
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Publications

Breviscapine alleviates NASH by inhibiting TGF-β-activated kinase 1-dependent signaling.

Lan Tian T   Jiang Shuo S   Zhang Jing J   Weng Qiqing Q   Yu Yang Y   Li Haonan H   Tian Song S   Ding Xin X   Hu Sha S   Yang Yiqi Y   Wang Weixuan W   Wang Lexun L   Luo Duosheng D   Xiao Xue X   Piao Shenghua S   Zhu Qing Q   Rong Xianglu X   Guo Jiao J  

Hepatology (Baltimore, Md.) 20211219 1


<h4>Background and aims</h4>NAFLD is a key component of metabolic syndrome, ranging from nonalcoholic fatty liver to NASH, and is now becoming the leading cause of cirrhosis and HCC worldwide. However, due to the complex and unclear pathophysiological mechanism, there are no specific approved agents for treating NASH. Breviscapine, a natural flavonoid prescription drug isolated from the traditional Chinese herb Erigeron breviscapus, exhibits a wide range of pharmacological properties, including  ...[more]

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