Transcriptomics

Dataset Information

5

Transcriptional analysis of wild-type Leishmania species between both stages using full-genome DNA microarrays


ABSTRACT: Transcriptional analyses of L. infantum promastigote compared to L. infantum intracellular amastigote, and L. major promastigote compared to L. major intracellular amastigote The full-genome DNA microarray includes one 70mer-oligonucleotide probe for each gene of L. infantum and for each gene of L.major LV39 Keywords: stage-specific comparison Leishmania infantum: Two-condition experiment, promastigote stage vs amastigote stage. Six biological replicates for each stage, independently grown and harvested. One replicate per array Leishmania major: Two-condition experiment, promastigote stage vs amastigote stage. Four biological replicates for each stage, independently grown and harvested. One replicate per array

SUBMITTER: P Rigault   A Rochette  S Boisvert  B Papadopoulou  F Raymond  J M Ubeda  Barbara Papadopoulou  J Corbeil  M Ouellette  M Smith  N Messier 

PROVIDER: E-GEOD-10407 | ArrayExpress | 2008-05-28

SECONDARY ACCESSION(S): GSE10407PRJNA108045

REPOSITORIES: GEO, ArrayExpress

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Publications

Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species.

Rochette Annie A   Raymond Frédéric F   Ubeda Jean-Michel JM   Smith Martin M   Messier Nadine N   Boisvert Sébastien S   Rigault Philippe P   Corbeil Jacques J   Ouellette Marc M   Papadopoulou Barbara B  

BMC genomics 20080529


BACKGROUND: Leishmania parasites cause a diverse spectrum of diseases in humans ranging from spontaneously healing skin lesions (e.g., L. major) to life-threatening visceral diseases (e.g., L. infantum). The high conservation in gene content and genome organization between Leishmania major and Leishmania infantum contrasts their distinct pathophysiologies, suggesting that highly regulated hierarchical and temporal changes in gene expression may be involved. RESULTS: We used a multispecies DNA ol  ...[more]

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