Dataset Information


Comparison of endocrine enriched genes in islet beta cells versus induced beta cells

ABSTRACT: Endocrine enriched genes in adult islet beta cells were identified and compared with that of induced beta cells (with M3 transcription factors) in adult. The control sample is non-beta pancreatic cells. Gene expression profile comparison of 3 samples, 3 independent repeats for each sample indicate a high degree of similarity between endogenous and induced beta cells in adult mouse.

ORGANISM(S): Mus musculus  

SUBMITTER: Qiao Zhou   qiao zhou 

PROVIDER: E-GEOD-12025 | ArrayExpress | 2008-07-08



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In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.

Zhou Qiao Q   Brown Juliana J   Kanarek Andrew A   Rajagopal Jayaraj J   Melton Douglas A DA  

Nature 20080827 7213

One goal of regenerative medicine is to instructively convert adult cells into other cell types for tissue repair and regeneration. Although isolated examples of adult cell reprogramming are known, there is no general understanding of how to turn one cell type into another in a controlled manner. Here, using a strategy of re-expressing key developmental regulators in vivo, we identify a specific combination of three transcription factors (Ngn3 (also known as Neurog3) Pdx1 and Mafa) that reprogra  ...[more]

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