Transcriptomics

Dataset Information

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Transcription profiling by array of human MCF10A cells over-expressing HRas or MEK1


ABSTRACT: MCF10A cells were then transfected with MEK1(S217S221), HRAS(G12V), and null control vectors; Cells were lysed 24 hours post-transfection with collection of total RNA and protein Experiment Overall Design: Overexpression of Oncogenic protein was confirmed via Western blot

REANALYSED by: E-GEOD-12764

OTHER RELATED OMICS DATASETS IN: E-GEOD-29327

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Tom Januario  

PROVIDER: E-GEOD-12764 | ArrayExpress | 2009-01-17

SECONDARY ACCESSION(S): GSE12764PRJNA114163

REPOSITORIES: GEO, ArrayExpress

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Publications


The basal-like subtype of breast cancer has an aggressive clinical behavior compared to that of the luminal subtype. We identified the microRNAs (miRNAs) miR-221 and miR-222 (miR-221/222) as basal-like subtype-specific miRNAs and showed that expression of miR-221/222 decreased expression of epithelial-specific genes and increased expression of mesenchymal-specific genes, and increased cell migration and invasion in a manner characteristic of the epithelial-to-mesenchymal transition (EMT). The tr  ...[more]

Publication: 1/2

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