Transcriptomics,Multiomics

Dataset Information

3

H4K12 acetylation in Human Spermatozoa


ABSTRACT: H4K12 acetylation mapped by chromatin Chromatin immunoprecipitation (ChIP) in human sperm. ChIP mapping of chromatin modification. Three biological replicates hybridized to each of two chips.

ORGANISM(S): Homo Sapiens

SUBMITTER: Philip Tedder   Klaus Steger  Ali Arpanahi  Agnieszka Paradowska  David Miller  Stephen A Krawetz  Adrian E Platts  David Iles  Martin Brinkworth 

PROVIDER: E-GEOD-13101 | ArrayExpress | 2010-05-18

SECONDARY ACCESSION(S): GSE13101PRJNA114071

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-13101.README.txt Txt
E-GEOD-13101.idf.txt Idf
E-GEOD-13101.processed.1.zip Processed
E-GEOD-13101.raw.1.zip Raw
E-GEOD-13101.raw.2.zip Raw
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Publications

Endonuclease-sensitive regions of human spermatozoal chromatin are highly enriched in promoter and CTCF binding sequences.

Arpanahi Ali A   Brinkworth Martin M   Iles David D   Krawetz Stephen A SA   Paradowska Agnieszka A   Platts Adrian E AE   Saida Myriam M   Steger Klaus K   Tedder Philip P   Miller David D  

Genome research 20090707 8


During the haploid phase of mammalian spermatogenesis, nucleosomal chromatin is ultimately repackaged by small, highly basic protamines to generate an extremely compact, toroidal chromatin architecture that is critical to normal spermatozoal function. In common with several species, however, the human spermatozoon retains a small proportion of its chromatin packaged in nucleosomes. As nucleosomal chromatin in spermatozoa is structurally more open than protamine-packaged chromatin, we considered  ...[more]

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