Transcriptomics

Dataset Information

2

Transcription profiling of human primary hepatocytes treated with acetaminophen in sandwich-cultured cells


ABSTRACT: Gene expression profiles of sandwich-cultured primary human hepatocytes exposed to 5 mM and 10 mM acetaminophen were used in a parallelogram approach in order to compare gene expression responses between rat and human using in vitro cellular models, hepatocytes, and between rat in vitro and in vivo. Experiment Overall Design: Samples were retrieved from acetaminophen treated human hepatocyte cultures from 5 individuals (5 biological replicates). Experiment Overall Design: Human hepatocytes from each replicate were treated with 0, 5, and 10 mM acetaminophen for 24 h. Experiment Overall Design: This resulted in (3x5) 15 dual channel arrays on which control (0 mM acetaminophen) and reference samples (0, 5, and 10 mM acetaminophen) were hybridized.

ORGANISM(S): Homo sapiens  

SUBMITTER: Anne Susan Kienhuis  

PROVIDER: E-GEOD-13430 | ArrayExpress | 2009-01-14

SECONDARY ACCESSION(S): GSE13430PRJNA110013

REPOSITORIES: GEO, ArrayExpress

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