Transcriptomics

Dataset Information

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Transcription profiling by array of human cervical cancer cells after RNAi-mediated knockdown of DGCR8 and Drosha


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE13638: Ago2 or Dicer knockdown effects on mRNA levels in HeLa GSE13639: Drosha or DGCR8 knockdown effects on mRNA levels in HeLa Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Jinju Han  

PROVIDER: E-GEOD-13640 | ArrayExpress | 2009-01-15

SECONDARY ACCESSION(S): GSE13640PRJNA110187

REPOSITORIES: GEO, ArrayExpress

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Publications


The Drosha-DGCR8 complex, also known as Microprocessor, is essential for microRNA (miRNA) maturation. Drosha functions as the catalytic subunit, while DGCR8 (also known as Pasha) recognizes the RNA substrate. Although the action mechanism of this complex has been intensively studied, it remains unclear how Drosha and DGCR8 are regulated and if these proteins have any additional role(s) apart from miRNA processing. Here, we report that Drosha and DGCR8 regulate each other posttranscriptionally. T  ...[more]

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