Transcriptomics

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Comparison of CD4+ T cell function between HIV-1 resistant and HIV-1 susceptible individuals (Immune)


ABSTRACT: Understanding why some indidivual resist HIV-1 infection despite continued exposure is an important goal for vaccine development. We compared CD4+ T cell gene expression at baseline and after antigenic stimulation in HIV-1 resistant commercial sex-workers from Nairobi, Kenya to HIV-1 low-risk negative (non-resistant) non-commercial sex-workers using immune-focused gene expression arrays Keywords: Case-control, disease state analysis CD4+ T cells from both HIV resistant and HIV low-risk negative individuals were isolated from PBMC after 24 hours of culture by negative slelction. Total RNA was isolated and gene expression compared using immune-focused expression arrays.

ORGANISM(S): Homo sapiens  

SUBMITTER: T B Ball   Walter Jaoko  Roland Somogyi  Joshua Kimani  Francis A Plummer  Paul J McLaren  Larry D Greller  Ali Danesh  David J Kelvin  Keith R Fowke  Paul McLaren  Charles Wachihi  Michael Mayne 

PROVIDER: E-GEOD-14279 | ArrayExpress | 2010-03-01

SECONDARY ACCESSION(S): GSE14279PRJNA114565

REPOSITORIES: GEO, ArrayExpress

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