Transcriptomics

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Molecular profiling of breast cancer cell lines defines relevant tumor models


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE13914: Molecular profiling of breast cancer cell lines defines relevant tumor models (aCGH) GSE15361: Molecular profiling of breast cancer cell lines defines relevant tumor models (gene expression) Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Jonathan Pollack  

PROVIDER: E-GEOD-15376 | ArrayExpress | 2010-06-25

SECONDARY ACCESSION(S): GSE15376PRJNA117105

REPOSITORIES: GEO, ArrayExpress

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Publications

Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.

Kao Jessica J   Salari Keyan K   Bocanegra Melanie M   Choi Yoon-La YL   Girard Luc L   Gandhi Jeet J   Kwei Kevin A KA   Hernandez-Boussard Tina T   Wang Pei P   Gazdar Adi F AF   Minna John D JD   Pollack Jonathan R JR  

PloS one 20090703 7


BACKGROUND:Breast cancer cell lines have been used widely to investigate breast cancer pathobiology and new therapies. Breast cancer is a molecularly heterogeneous disease, and it is important to understand how well and which cell lines best model that diversity. In particular, microarray studies have identified molecular subtypes-luminal A, luminal B, ERBB2-associated, basal-like and normal-like-with characteristic gene-expression patterns and underlying DNA copy number alterations (CNAs). Here  ...[more]

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