Dataset Information


Transcription profiling of mouse whole brain gene expression in X-monosomic and normal female mice

ABSTRACT: Whole brain gene expression was examined in the following strains of mice: 1. P0 maternal monosomic 39,Xm females, C57BL/6J x C3H/Paf; 2. P0 paternal monosomic 39, Xp females, In(X)/C3H x C57BL/6J; 3. P0 normal 40,XX females, In(X)/C3H x C57BL/6J; 4. P0 normal 40,XX females, C57BL/6J x C3H/Paf

ORGANISM(S): Mus musculus  

SUBMITTER: Adam S. Raefski  

PROVIDER: E-GEOD-1606 | ArrayExpress | 2007-10-11



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Identification of a cluster of X-linked imprinted genes in mice.

Raefski Adam S AS   O'Neill Michael J MJ  

Nature genetics 20050522 6

Complete or partial monosomy with respect to the X chromosome is the genetic basis of Turner syndrome in human females. Individuals with Turner syndrome have a spectrum of anatomical, physiological and behavioral phenotypes with expressivity dependent on the extent of monosomy and the parental origin of the single X. Parent-of-origin influences on social cognition in Turner syndrome might be due to the presence of imprinted genes on the X. Imprinting of X-linked genes has also been implicated in  ...[more]

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