Transcriptomics

Dataset Information

23

Broad defects in epidermal cornification in atopic dermatitis (AD) identified through genomic analysis


ABSTRACT: In this study we used genomic profiling to characterize differences in expression of genes related to epidermal growth/differentiation and inflammatory circuits in skin lesions of psoriasis and atopic dermatitis (AD), comparing expression values to normal skin. Skin biopsies were collected from 9 patients with chronic atopic dermatitis, 15 psoriasis patients, and 9 healthy volunteers. Keywords: Genetic-pathology Psoriasis and AD are common inflammatory skin diseases which share important features, including: 1) large infiltrates of T-cells and inflammatory dendritic cells in skin lesions, 2) immune activation with up-regulated expression of many cytokines, chemokines, and inflammatory molecules 3) marked epidermal hyperplasia in chronic diseased skin and 4) defective barrier function with increased transepidermal water loss (TEWL), which reflects underlying alterations in keratinocyte differentiation. Using genomic profiling we provide a comprehensive comparison of chronic psoriasis and AD skin lesions as compared with normal skin.

REANALYSED by: E-GEOD-16161

ORGANISM(S): Homo sapiens  

SUBMITTER: Mayte Suárez-Fariñas   Mayte Suarez-Farinas  James G Krueger  Emma Guttman-Yassky 

PROVIDER: E-GEOD-16161 | ArrayExpress | 2009-10-31

SECONDARY ACCESSION(S): GSE16161PRJNA117185

REPOSITORIES: GEO, ArrayExpress

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Publications

Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis.

Guttman-Yassky Emma E   Suárez-Fariñas Mayte M   Chiricozzi Andrea A   Nograles Kristine E KE   Shemer Avner A   Fuentes-Duculan Judilyn J   Cardinale Irma I   Lin Peng P   Bergman Reuven R   Bowcock Anne M AM   Krueger James G JG  

The Journal of allergy and clinical immunology 20091201 6


Psoriasis and atopic dermatitis (AD) are common, complex inflammatory skin diseases. Both diseases display immune infiltrates in lesions and epidermal growth/differentiation alterations associated with a defective skin barrier. An incomplete understanding of differences between these diseases makes it difficult to compare human disease pathology to animal disease models.To characterize differences between these diseases in expression of genes related to epidermal growth/differentiation and infla  ...[more]

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