Transcriptomics

Dataset Information

0

Expression profiles of mouse glioma-initiating cell-like subclones


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Toru Kondo  

PROVIDER: E-GEOD-17101 | ArrayExpress | 2009-12-01

SECONDARY ACCESSION(S): GSE17101PRJNA117823

REPOSITORIES: GEO, ArrayExpress

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Publications

Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation.

Hide Takuichiro T   Takezaki Tatsuya T   Nakatani Yuka Y   Nakamura Hideo H   Kuratsu Jun-ichi J   Kondo Toru T  

Cancer research 20091006 20


Recent findings have shown that malignant tumors contain cancer-initiating cells (CIC), which self-renew and are tumorigenic. However, CICs have not been characterized properly due to lack of specific markers. We recently established a mouse glioma cell line, NSCL61, by overexpressing an oncogenic HRas(L61) in p53-deficient neural stem cells. Using limiting dilution assays, we show that only 2 of 24 NSCL61 clones retained their tumorigenicity in vivo, although the others also expressed oncogenic  ...[more]

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