Dataset Information


MiRNA expression, mRNA expression upon miRNA reconstitution, and direct mRNA target identification in prostate cancer cell lines

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE17315: mRNA expression upon reconstitution of miR-130a, miR-203 and miR-205 in prostate cancer cell line LNCaP GSE17317: miRNA expression in LNCaP, PC3, Du-145 and RWPE-1 cell lines GSE22979: Profiling of direct mRNA targets of miR-130a, miR-203 and miR-205 in prostate cancer cell line LNCaP Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Gerald Verhaegh   Katharina Kasack  Nora Mörbt  Friedemann Horn  Janina Tomm  Kerstin Boll  Kristin Reiche  Jack Schalken  Jörg Hackermüller  Antje K Kretzschmar  Martin von Bergen 

PROVIDER: E-GEOD-17362 | ArrayExpress | 2012-03-07



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MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma.

Boll K K   Reiche K K   Kasack K K   Mörbt N N   Kretzschmar A K AK   Tomm J M JM   Verhaegh G G   Schalken J J   von Bergen M M   Horn F F   Hackermüller J J  

Oncogene 20120305 3

With ∼30 000 deaths annually in the United States, prostate cancer (PCa) is a major oncologic disease. Here we show that the microRNAs miR-130a, miR-203 and miR-205 jointly interfere with the two major oncogenic pathways in prostate carcinoma and are downregulated in cancer tissue. Using transcriptomics we show that the microRNAs repress several gene products known to be overexpressed in this cancer. Argonaute 2 (AGO2) co-immunoprecipitation, reporter assays and western blot analysis demonstrate  ...[more]

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