Transcriptomics

Dataset Information

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Expression data from breast cancer cells overexpressing NF1-C2


ABSTRACT: NF1-C2 suppresses tumorigenesis and epithelial-to-mesenchymal transition by repressing FoxF1. We used microarray to identify direct targets for NF1-C2. The human breast tumor cell line MDA-MB-436 were stably transfected with an expression plasmid including NF1-C2. RNA from these cells and wildtype cells were extracted and hybridized on Affymetrix microarrays (platform GPL570). Three replicates each.

REANALYSED by: E-GEOD-17636

ORGANISM(S): Homo sapiens  

SUBMITTER: Jeanette Nilsson  Marie K Janson    

PROVIDER: E-GEOD-17636 | ArrayExpress | 2010-03-09

SECONDARY ACCESSION(S): GSE17636PRJNA118575

REPOSITORIES: GEO, ArrayExpress

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Publications

Nuclear Janus-activated kinase 2/nuclear factor 1-C2 suppresses tumorigenesis and epithelial-to-mesenchymal transition by repressing Forkhead box F1.

Nilsson Jeanette J   Helou Khalil K   Kovács Anikó A   Bendahl Pär-Ola PO   Bjursell Gunnar G   Fernö Mårten M   Carlsson Peter P   Kannius-Janson Marie M  

Cancer research 20100209 5


Progression to metastasis is the proximal cause of most cancer-related mortality. Yet much remains to be understood about what determines the spread of tumor cells. This paper describes a novel pathway in breast cancer that regulates epithelial-to-mesenchymal transition (EMT), motility, and invasiveness. We identify two transcription factors, nuclear factor 1-C2 (NF1-C2) and Forkhead box F1 (FoxF1), downstream of prolactin/nuclear Janus-activated kinase 2, with opposite effects on these processe  ...[more]

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