Transcriptomics

Dataset Information

16

Transcription profiling of human normal, premalignant and various histological subtypes of testicular germ cell tumor (TGCT) tissues, and of two TGCT cell lines treated with retinoic acid


ABSTRACT: Normal, premalignant and various histological subtypes of testicular germ cell tumor (TGCT) tissues were hybridized against Universal Human Reference RNA (Stratagene) onto Agilent 60mer oligo microarrays (GEO accession no GPL885). In vitro time series of two TGCT cell lines, NTERA2 and 2102Ep, treated with retinoic acid for 0, 3, and 7 days were also included. The data set (30 hybridizations) is particularly useful for comparisons between various histological subtypes of TGCT versus each other or versus normal testis.

Data were imported from their GEO record, which contains no information about which dyes were scanned in which channels. CH1 and CH2 have therefore been used throughout.

ORGANISM(S): Homo sapiens  

DISEASE(S): Choriocarcinoma,Seminoma,Teratoma,Yolk Sac Tumor,Premalignant Neoplasia,Normal,Embryonal Carcinoma,Malignant Testicular Germ Cell Tumor

SUBMITTER: Rolf I. Skotheim  

PROVIDER: E-GEOD-1818 | ArrayExpress | 2008-05-07

SECONDARY ACCESSION(S): GDS1742GSE1818PRJNA90499

REPOSITORIES: GEO, ArrayExpress

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Publications

Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development.

Skotheim Rolf I RI   Lind Guro E GE   Monni Outi O   Nesland Jahn M JM   Abeler Vera M VM   Fosså Sophie D SD   Duale Nur N   Brunborg Gunnar G   Kallioniemi Olli O   Andrews Peter W PW   Lothe Ragnhild A RA  

Cancer research 20050701 13


Embryonal carcinoma is a histologic subgroup of testicular germ cell tumors (TGCTs), and its cells may follow differentiation lineages in a manner similar to early embryogenesis. To acquire new knowledge about the transcriptional programs operating in this tumor development model, we used 22k oligo DNA microarrays to analyze normal and neoplastic tissue samples from human testis. Additionally, retinoic acid-induced in vitro differentiation was studied in relevant cell lines. We identified genes  ...[more]

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