Transcriptomics

Dataset Information

37

Expression analysis in yeast model of Huntington's disease (HD)


ABSTRACT: Expressing a mutant fragment of huntingtin (Htt) in yeast produces several HD-relevant phenotypes. We used microarrays to study global change in expression induced by this mutant htt fragment. Expression was also analysed in three suppressor deletion strains expressing a toxic mutant htt fragment: bna4Δ, mbf1Δ, and ume1Δ. Yeast samples expressing either a wild-type or mutant htt fragment (Htt25Q or Htt103Q, respectively), and suppressor deletion strains expressing Htt103Q: bna4Δ, mbf1Δ, and ume1Δ.

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Flaviano Giorgini  Eran Tauber    

PROVIDER: E-GEOD-18644 | ArrayExpress| 2012-03-27

SECONDARY ACCESSION(S): GSE18644PRJNA121577

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity.

Tauber Eran E   Miller-Fleming Leonor L   Mason Robert P RP   Kwan Wanda W   Clapp Jannine J   Butler Nicola J NJ   Outeiro Tiago F TF   Muchowski Paul J PJ   Giorgini Flaviano F  

The Journal of biological chemistry 20101102 1


Huntington disease (HD) is a neurodegenerative disorder caused by the expansion of a polyglutamine tract in the huntingtin (htt) protein. To uncover candidate therapeutic targets and networks involved in pathogenesis, we integrated gene expression profiling and functional genetic screening to identify genes critical for mutant htt toxicity in yeast. Using mRNA profiling, we have identified genes differentially expressed in wild-type yeast in response to mutant htt toxicity as well as in three to  ...[more]

Similar Datasets

2010-11-09 | GSE18644 | GEO
2008-09-01 | GSE12481 | GEO
2011-06-10 | E-GEOD-12481 | ArrayExpress
2011-06-10 | E-GEOD-1918 | ArrayExpress
2014-05-31 | E-GEOD-54443 | ArrayExpress
| GSE43429 | GEO
| GSE65764 | GEO
2015-09-02 | E-GEOD-15203 | ExpressionAtlas
2015-09-02 | E-GEOD-15202 | ExpressionAtlas
2014-05-02 | E-GEOD-43430 | ArrayExpress