Transcriptomics

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Transcription profiling of IFN-gamma transcriptional responses in control and IFN-gamma primed primary human macrophages


ABSTRACT: IFN-gamma transcriptional responses in control and IFN-gamma primed primary human macrophages

ORGANISM(S): Homo sapiens  

SUBMITTER: Xiaoyu Hu   

PROVIDER: E-GEOD-1925 | ArrayExpress | 2007-09-01

SECONDARY ACCESSION(S): GSE1925GDS1365PRJNA90953

REPOSITORIES: GEO, ArrayExpress

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Publications

IFN-gamma-primed macrophages exhibit increased CCR2-dependent migration and altered IFN-gamma responses mediated by Stat1.

Hu Xiaoyu X   Park-Min Kyung-Hyun KH   Ho Hao H HH   Ivashkiv Lionel B LB  

Journal of immunology (Baltimore, Md. : 1950) 20050901 6


Priming of macrophages with IFN-gamma increases cellular responsiveness to inflammatory stimuli, including IFN-gamma itself. We described previously that priming with subactivating concentrations of IFN-gamma increased Stat1 expression and resulted in enhanced activation of Stat1 and of a subset of IFN-gamma-responsive genes when primed macrophages were restimulated with low doses of IFN-gamma. In this study, we determined the effects of IFN-gamma priming on the macrophage transcriptome and on t  ...[more]

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