Dataset Information


Expression analysis of zebrafish TIF1g-deficient, cdc73 deficient and double-deficient embryos

ABSTRACT: Investigation of whole genome gene expression level changes in zebrafish TIF1g-deficient, cdc73 deficient and double-deficient embryos, compared to the wild-type ebryos. A twelve-chip study using total RNA isolated from gata1-GFP positive cells (sorted by FACS) from 12 somite-stage wild type embryos, TIF1g morholino injected, Cdc73 morpholino injected and double morpholino injected embryos.

ORGANISM(S): Danio rerio  

SUBMITTER: Xiaoying Bai   Leonard I Zon 

PROVIDER: E-GEOD-20432 | ArrayExpress | 2010-07-13



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Recent genome-wide studies have demonstrated that pausing of RNA polymerase II (Pol II) occurred on many vertebrate genes. By genetic studies in the zebrafish tif1gamma mutant moonshine we found that loss of function of Pol II-associated factors PAF or DSIF rescued erythroid gene transcription in tif1gamma-deficient animals. Biochemical analysis established physical interactions among TIF1gamma, the blood-specific SCL transcription complex, and the positive elongation factors p-TEFb and FACT. Ch  ...[more]

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