Transcriptomics

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Human Nephrosclerosis Triggers a Hypoxia-Related Glomerulopathy


ABSTRACT: Expression data from microdissected glomeruli to examine the role of hypoxia in glomerulosclerosis of human Nephrosclerosis (NSC). Human Kidney biopsies of patients with NSC (n=14) and TN (n=4) were selected for RNA extraction and hybridization on Affymetrix microarrays. Gene expression data was then analysed using Genepattern and Genomatix software suites which revealed that CXCR4/CXCL12 plays a role in human NSC and therefore indicate that hypoxia contributes to glomerular damage in NSC.

REANALYSED by: E-GEOD-20602

ORGANISM(S): Homo sapiens  

SUBMITTER: Matthias A Neusser  Matthias Kretzler   Preethi Sankaranarayanan    

PROVIDER: E-GEOD-20602 | ArrayExpress | 2010-04-07

SECONDARY ACCESSION(S): GSE20602PRJNA124773

REPOSITORIES: GEO, ArrayExpress

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Publications


In the kidney, hypoxia contributes to tubulointerstitial fibrosis, but little is known about its implications for glomerular damage and glomerulosclerosis. Chronic hypoxia was hypothesized to be involved in nephrosclerosis (NSC) or "hypertensive nephropathy." In the present study genome-wide expression data from microdissected glomeruli were studied to examine the role of hypoxia in glomerulosclerosis of human NSC. Functional annotation analysis revealed prominent regulation of hypoxia-associate  ...[more]

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