Dataset Information


Transcription profiling of uteri from mice treated with 17beta-estradiol for different durations to study the molecular mechanism for estrogen induced uterine growth.

ABSTRACT: Immature (19/20 days of age) Alpk:APfCD-1 mice were treated with arachis oil (AO) vehicle or 0.4mg/kg 17beta-estradiol (E2), via a single subcutaneous injection, and sacrificed at 1hr, 2hr, 4hr, 8hr, 24hr, 48hr, 72hr post dose.

ORGANISM(S): Mus musculus  

SUBMITTER: Fei Ling Lim  

PROVIDER: E-GEOD-2195 | ArrayExpress | 2007-09-22



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Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth.

Moggs Jonathan G JG   Tinwell Helen H   Spurway Tracey T   Chang Hur-Song HS   Pate Ian I   Lim Fei Ling FL   Moore David J DJ   Soames Anthony A   Stuckey Ruth R   Currie Richard R   Zhu Tong T   Kimber Ian I   Ashby John J   Orphanides George G  

Environmental health perspectives 20041101 16

A major challenge in the emerging field of toxicogenomics is to define the relationships between chemically induced changes in gene expression and alterations in conventional toxicologic parameters such as clinical chemistry and histopathology. We have explored these relationships in detail using the rodent uterotrophic assay as a model system. Gene expression levels, uterine weights, and histologic parameters were analyzed 1, 2, 4, 8, 24, 48, and 72 hr after exposure to the reference physiologi  ...[more]

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