Transcriptomics

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Global transcriptomic profiling of nitric oxide-mediated neuronal death


ABSTRACT: Nitric oxide (NO) is implicated in the pathogenesis of various neuropathologies characterised by oxidative stress. NO has been reported to be involved in the exacerbation of oxidative stress by various mechanisms, including protein modification, genotoxic damage and elevated production of reactive oxygen species resulting in deregulation and disruption of cellular homeostasis. Although multiple roles for NO has been reported in neuronal death signaling, existent data fail to provide a holistic description of how nitrergic pathobiology elicits neuronal injury. Here we provide a comprehensive description of mechanisms contributing to NO-induced neuronal injury by global transcriptomic profiling. Microarray analysis was carried out using 14 GeneChip Mouse Genome 430 2.0 array (Affymetrix, Santa Clara, CA). The assignment of the arrays (GeneChip) was as follows: vehicle-treated control (n=5); NOC-18-treatment for 8, 15 and 24 hour (n=3 for each time-point).

ORGANISM(S): Mus musculus  

SUBMITTER: Nam S Cheung   Jayapal Manikandan  Minghui J Chen  Zhao F Peng  Minghui Jessica Chen 

PROVIDER: E-GEOD-22087 | ArrayExpress | 2013-01-23

SECONDARY ACCESSION(S): GSE22087PRJNA128937

REPOSITORIES: GEO, ArrayExpress

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Publications

Multifaceted role of nitric oxide in an in vitro mouse neuronal injury model: transcriptomic profiling defines the temporal recruitment of death signalling cascades.

Peng Zhao Feng ZF   Chen Minghui Jessica MJ   Manikandan Jayapal J   Melendez Alirio J AJ   Shui Guanghou G   Russo-Marie Françoise F   Whiteman Matthew M   Beart Philip M PM   Moore Philip K PK   Cheung Nam Sang NS  

Journal of cellular and molecular medicine 20120101 1


Nitric oxide is implicated in the pathogenesis of various neuropathologies characterized by oxidative stress. Although nitric oxide has been reported to be involved in the exacerbation of oxidative stress observed in several neuropathologies, existent data fail to provide a holistic description of how nitrergic pathobiology elicits neuronal injury. Here we provide a comprehensive description of mechanisms contributing to nitric oxide induced neuronal injury by global transcriptomic profiling. Mi  ...[more]

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