Transcriptomics

Dataset Information

0

Comparison of splenic and small intestine lamina propria dendritic cells


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE22127: Expression profiling of small intestine lamina propria dendritic cells GSE22128: Expression profiling of splenic dendritic cells Dendritic cells play a vital role in initiating robust immunity against pathogens as well as maintaining immunological tolerance to self antigens, food antigens and intestinal commensals. However, the intracellular signaling networks that program DCs to become tolerogenic are largely unknown. To address this, we analyzed gene expression profiles using microarray analysis of purified intestinal lamina propria DCs (CD11c+ CD11b+ DCs and CD11c+ CD11b- DCs) and compared it to splenic DCs (CD11c+ DC), from mice. We sought to determine the unique genetic profile of small intestine lamina propria CD11c+ cells compared to splenic CD11c+ cells. We performed a meta-analysis using the expression profiles of Intestinal lamina propria CD11c+ CD11b+ DCs (GSM550122), Intestinal lamina propria CD11c+ CD11b- DCs (GSM550121) and Splenic CD11c+ DCs (GSM550126). This study combined and re-normalized the microarray data from GSE22127 and GSE22128 studies. Refer to individual Series for additional details

ORGANISM(S): Mus musculus  

SUBMITTER: Helder I Nakaya   

PROVIDER: E-GEOD-22136 | ArrayExpress | 2010-06-16

SECONDARY ACCESSION(S): GSE22136PRJNA127573

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets

2010-06-16 | E-GEOD-22127 | ArrayExpress
| GSE22136 | GEO
2008-06-16 | E-GEOD-8868 | ArrayExpress
2010-06-05 | GSE22127 | GEO
2010-06-16 | E-GEOD-22128 | ArrayExpress
| GSE77545 | GEO
2011-10-31 | GSE31551 | GEO
2011-10-31 | E-GEOD-31551 | ArrayExpress
2007-08-24 | GSE8868 | GEO
2011-12-21 | GSE27859 | GEO