Transcriptomics,Genomics

Dataset Information

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An integrative analysis of the SOX2 response program in glioblastoma


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE23795: Chip-Seq analysis of Sox2 protein genome-wide DNA binding sites in glioma cancer cells GSE23838: Genes regulated by Sox2 in glioma cancer cell line Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Biao Yang Lin   

PROVIDER: E-GEOD-23839 | ArrayExpress | 2011-01-10

SECONDARY ACCESSION(S): GSE23839PRJNA130651

REPOSITORIES: GEO, ArrayExpress

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Publications

The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis.

Fang Xuefeng X   Yoon Jae-Geun JG   Li Lisha L   Yu Wei W   Shao Jiaofang J   Hua Dasong D   Zheng Shu S   Hood Leroy L   Goodlett David R DR   Foltz Gregory G   Lin Biaoyang B  

BMC genomics 20110106


BACKGROUND: SOX2 is a key gene implicated in maintaining the stemness of embryonic and adult stem cells. SOX2 appears to re-activate in several human cancers including glioblastoma multiforme (GBM), however, the detailed response program of SOX2 in GBM has not yet been defined. RESULTS: We show that knockdown of the SOX2 gene in LN229 GBM cells reduces cell proliferation and colony formation. We then comprehensively characterize the SOX2 response program by an integrated analysis using several a  ...[more]

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