Transcriptomics

Dataset Information

4

Transcription profiling of liver from rats orally exposed to effluent from drug manufacturing to detect potential short-term effects


ABSTRACT: The Patancheru area near Hyderabad in India is recognized as a key link in the global supply chain for many bulk drugs. A central treatment plant receives wastewater from about 90 different manufacturers and the resulting complex effluent has contaminated surface, ground and drinking water in the region. Ecotoxicological testing of the effluent has shown adverse effects for several organisms, including aquatic vertebrates. In an attempt to start investigating how exposure to effluent-contaminated water may affect humans and other terrestrial vertebrates, rats were tube-fed effluent. Results from microarray and quantitative polymerase chain reaction assays indicated, however, no marked effects on hepatic gene expression after five days exposure. Neither did a clinical analysis of blood serum constituents used as biomarkers for human disease reveal any significant changes, nor were there any effects on weight gain. Taken together, we could not find evidence for any acute toxicity in the rat; however, we cannot rule out that higher doses of effluent or a longer exposure time may still be associated with risks for terrestrial vertebrates. 10 rats (5 controls and 5 exposed to effluent) were subjected to microarray analysis. Further information is available in Rutgersson et al., 2010.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Erik Kristiansson  

PROVIDER: E-GEOD-23983 | ArrayExpress | 2012-09-01

REPOSITORIES: ArrayExpress

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Publications

Oral exposure to industrial effluent with exceptionally high levels of drugs does not indicate acute toxic effects in rats.

Rutgersson Carolin C   Gunnarsson Lina L   Fick Jerker J   Kristiansson Erik E   Larsson D G Joakim DG  

Environmental toxicology and chemistry 20130301 3


The Patancheru area near Hyderabad in India is recognized as a key link in the global supply chain for many bulk drugs. A central treatment plant receives wastewater from approximately 90 different manufacturers, and the resulting complex effluent has contaminated surface, ground, and drinking water in the region. Ecotoxicological testing of the effluent has shown adverse effects for several organisms, including aquatic vertebrates, at high dilutions. In addition, a recent study of microbial com  ...[more]

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