Transcriptomics

Dataset Information

3

Expression analysis of 24hpf zebrafish embryos treated with Leflunomide 6.5uM


ABSTRACT: Identification of genes differentially regulated after treatment of zebrafish embryos from 50% epiboly to 24hpf with 6.5uM leflunomide A six chip study comparing expression levels of zebrafish embryos treated with leflunomide 6.5uM

ORGANISM(S): Danio rerio  

SUBMITTER: Richard Mark White  Richard White    

PROVIDER: E-GEOD-24527 | ArrayExpress | 2012-03-27

SECONDARY ACCESSION(S): GSE24527PRJNA132663

REPOSITORIES: GEO, ArrayExpress

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Publications


Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest. It is unknown to what extent the programs that regulate neural crest development interact with mutations in the BRAF oncogene, which is the most commonly mutated gene in human melanoma. We have used zebrafish embryos to identify the initiating transcriptional events that occur on activation of human BRAF(V600E) (which encodes an amino acid substitution mutant of BRAF) in the neural cres  ...[more]

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