Transcriptomics

Dataset Information

5

Expression analysis of zebrafish melanoma and skin from the mitf-BRAFV600E;p53-/- line


ABSTRACT: Investigation of expression differences between skin and melanomas from a transgenic BRAFV600E zebrafish model of melanoma The embryos described in this study are further analyzed in a manuscript submitted for publication by White, et al. A 15 chip study using RNA extracted from either WT zebrafish skin, mitf-BRAFV600E;p53-/- skin or mitf-BRAFV600E;p53-/- melanoma

ORGANISM(S): Danio rerio  

SUBMITTER: Richard M White   Richard Mark White 

PROVIDER: E-GEOD-24528 | ArrayExpress | 2011-03-30

SECONDARY ACCESSION(S): GSE24528PRJNA132665

REPOSITORIES: GEO, ArrayExpress

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Publications


Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest. It is unknown to what extent the programs that regulate neural crest development interact with mutations in the BRAF oncogene, which is the most commonly mutated gene in human melanoma. We have used zebrafish embryos to identify the initiating transcriptional events that occur on activation of human BRAF(V600E) (which encodes an amino acid substitution mutant of BRAF) in the neural cres  ...[more]

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