Transcriptomics

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Mut-16 and other mutator-class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans


ABSTRACT: Argonaute-associated siRNAs and Piwi-associated piRNAs have overlapping roles in silencing mobile genetic elements in animals. In C. elegans, mutator-class (mut) genes mediate siRNA-guided repression of transposons as well as exogenous RNA-directed gene silencing (RNAi), but their roles in endogenous RNA silencing pathways are not well understood. To characterize the endogenous small RNAs dependent on mutator-class genes, small RNA populations from a null allele of mut-16, as well as a regulatory mut-16(mg461) allele that disables only somatic RNAi, were subjected to deep sequencing. Small RNA analysis in wild type and mut-16 mutant C. elegans strains

ORGANISM(S): Caenorhabditis elegans  

SUBMITTER: Taiowa Montgomery   

PROVIDER: E-GEOD-26165 | ArrayExpress | 2011-02-01

SECONDARY ACCESSION(S): GSE26165SRP004901PRJNA135287

REPOSITORIES: GEO, ArrayExpress, ENA

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mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans.

Zhang Chi C   Montgomery Taiowa A TA   Gabel Harrison W HW   Fischer Sylvia E J SE   Phillips Carolyn M CM   Fahlgren Noah N   Sullivan Christopher M CM   Carrington James C JC   Ruvkun Gary G  

Proceedings of the National Academy of Sciences of the United States of America 20110118 4


Argonaute-associated siRNAs and Piwi-associated piRNAs have overlapping roles in silencing mobile genetic elements in animals. In Caenorhabditis elegans, mutator (mut) class genes mediate siRNA-guided repression of transposons as well as exogenous RNAi, but their roles in endogenous RNA silencing pathways are not well-understood. To characterize the endogenous small RNAs dependent on mut class genes, small RNA populations from a null allele of mut-16 as well as a regulatory mut-16(mg461) allele  ...[more]

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