Transcriptomics,Genomics

Dataset Information

68

A Bcl6-Smrt/Ncor repression program controls atherosclerosis


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE27001: Inhibition of Bcl6-SMRT/NCoR interactions by an inhibitory peptide affects inflammatory pathways GSE27033: Genome-wide location analysis of SMRT and NCoR in wild-type and Bcl6 knockout macrophages Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Ruth T Yu  

PROVIDER: E-GEOD-27060 | ArrayExpress | 2012-03-29

SECONDARY ACCESSION(S): GSE27060PRJNA137601

REPOSITORIES: GEO, ArrayExpress

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Publications


Chronic inflammation is a hallmark of atherosclerosis, but its transcriptional underpinnings are poorly understood. We show that the transcriptional repressor Bcl6 is an anti-inflammatory regulator whose loss in bone marrow of Ldlr(-/-) mice results in severe atherosclerosis and xanthomatous tendonitis, a virtually pathognomonic complication in patients with familial hypercholesterolemia. Disruption of the interaction between Bcl6 and SMRT or NCoR with a peptide inhibitor in vitro recapitulated  ...[more]

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