Transcriptomics

Dataset Information

10

Network inference tools for the human transcriptome


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE27869: Gene expression profiles of 400 siRNA knocked down on HUVEC GSE27870: The effect of TNFa on endothelial cells Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Hiromitsu Araki  

PROVIDER: E-GEOD-27871 | ArrayExpress | 2011-11-29

SECONDARY ACCESSION(S): GSE27871PRJNA138019

REPOSITORIES: GEO, ArrayExpress

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Publications


Gene regulatory networks inferred from RNA abundance data have generated significant interest, but despite this, gene network approaches are used infrequently and often require input from bioinformaticians. We have assembled a suite of tools for analysing regulatory networks, and we illustrate their use with microarray datasets generated in human endothelial cells. We infer a range of regulatory networks, and based on this analysis discuss the strengths and limitations of network inference from  ...[more]

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