Dataset Information


Gene expression profiles of pretreatment biopsies from dose-dense-docetaxel-treated breast cancers

ABSTRACT: The purpose of this study was to identify molecular markers of pathologic response to neoadjuvant dose-dense docetaxel treatment using gene expression profiling on pretreatment biopsies. Patients with high-risk, operable breast cancer were treated with 75 mg/m2 IV of docetaxel on day 1 of each cycle every 2 weeks x 4 cycles . Tumor tissue from pretreatment biopsies was obtained from 12 patients enrolled in the study. Gene expression profiling were done on serial sections of the biopsies from patients that achieved a pathologic complete response (pCR) and compared to those with residual disease, non-pCR (NR). Tumor tissues from pretreatment needle biopsies from patients enrolled in a dose-dense docetaxel clinical trial were laser capture microdissected for RNA extraction and hybridization to Affymetrix microarrays. We analyzed one array (sample A) from duplicate samples from each patient.

ORGANISM(S): Homo sapiens  

SUBMITTER: Jennifer A Pietenpol   Jennifer Pietenpol  Joshua A Bauer 

PROVIDER: E-GEOD-28796 | ArrayExpress | 2011-04-22



Similar Datasets

2011-04-22 | GSE28796 | GEO
2010-06-23 | GSE22513 | GEO
2010-06-23 | E-GEOD-22513 | ArrayExpress
| PRJNA138815 | ENA
| GSE54323 | GEO
2010-05-06 | E-GEOD-20444 | ArrayExpress
2015-04-14 | E-GEOD-54323 | ArrayExpress
2015-11-11 | E-GEOD-66999 | ArrayExpress
2012-12-01 | E-GEOD-35935 | ArrayExpress
2010-06-16 | E-GEOD-22128 | ArrayExpress