Transcriptomics

Dataset Information

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MiRNA expression profiling in Adult T-cell Leukemia (ATL) cells and in Normal CD4+ T-cells


ABSTRACT: HTLV-1 infected individuals stay as carriers for their lifetimes, while the rest of 5% are killed by ATL. ATL leukemogenesis is a complex process involving accumulation of multiple genetic abnormalities in HTLV-1 infected cells. To clarify genetic events underlying ATL leukemogenesis, we conducted comprehensive miRNA expression profiling in 40 ATL patients and in 22 healthy volunteers. Total RNA samples from PBMC of ATL patients (mostly HTLV-1 inefcted CD4+ T-cells) and from CD4+ T-cells from healthy donors were subjected to Cy-3 labeling followed by miRNA expression microarray analyses.

ORGANISM(S): Homo sapiens  

SUBMITTER: Y Kagami  Kazumi Nakano   A Tsutsumi   K Uchimaru   K Nakano   M Yamagishi   K Yamaguchi   T Watanabe   A Utsunomiya    

PROVIDER: E-GEOD-31629 | ArrayExpress | 2012-02-23

SECONDARY ACCESSION(S): GSE31629PRJNA145549

REPOSITORIES: GEO, ArrayExpress

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Publications


Constitutive NF-κB activation has causative roles in adult T cell leukemia (ATL) caused by HTLV-1 and other cancers. Here, we report a pathway involving Polycomb-mediated miRNA silencing and NF-κB activation. We determine the miRNA signatures and reveal miR-31 loss in primary ATL cells. MiR-31 negatively regulates the noncanonical NF-κB pathway by targeting NF-κB inducing kinase (NIK). Loss of miR-31 therefore triggers oncogenic signaling. In ATL cells, miR-31 level is epigenetically regulated,  ...[more]

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