Transcriptomics

Dataset Information

8

Effect of loss of function of Gal11/Med15 and Med3 from the Mediator tail module in budding yeast


ABSTRACT: Gene expression was compared for wild type yeast (BY4741) and yeast lacking Gal11/Med15 and Med3, or from a gal11-myc med3∆ strain. The gal11-myc allele shows a partial loss of function when combined with med3∆. Expression was analyzed for yeast grown in YPD as well as in CSM. We also examined gene expression of the wild type strain BY4742 grown in YPD and include that data here. Gene expression was compared for wild type yeast (BY4741 and BY4742) and yeast lacking Gal11/Med15 and Med3, or from a gal11-myc med3∆ strain.

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Randall H Morse   Suraiya A Ansari  Randall Heywood Morse 

PROVIDER: E-GEOD-31774 | ArrayExpress | 2011-08-31

SECONDARY ACCESSION(S): GSE31774PRJNA145277

REPOSITORIES: GEO, ArrayExpress

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Publications

Distinct role of Mediator tail module in regulation of SAGA-dependent, TATA-containing genes in yeast.

Ansari Suraiya A SA   Ganapathi Mythily M   Benschop Joris J JJ   Holstege Frank C P FC   Wade Joseph T JT   Morse Randall H RH  

The EMBO journal 20111004 1


The evolutionarily conserved Mediator complex is required for transcription of nearly all RNA Pol II-dependent promoters, with the tail module serving to recruit Mediator to active promoters in current models. However, transcriptional dependence on tail module subunits varies in a gene-specific manner, and the generality of the tail module requirement for transcriptional activation has not been explored. Here, we show that tail module subunits function redundantly to recruit Mediator to promoter  ...[more]

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