Transcriptomics

Dataset Information

4

Gene expression analysis of chickens (Gallus gallus) infected with recombinant influenza viruses


ABSTRACT: H5N1 subtype highly pathogenic avian influenza virus has been spreading to Asia, Eurasia and African coutries. An original or six of recombinant H5N1 subtype influenza viruses with varying survivability were infected to chickens for elucidating genes correlated with pathogenicity. Two chickens were infected with each 10^6EID50/ head virus intranasally, and their lung was collected from infected chicken at 24 hours after infection.

ORGANISM(S): Gallus gallus  

SUBMITTER: Yuko Uchida   Takehiko Saito  Takehiko Oka 

PROVIDER: E-GEOD-32378 | ArrayExpress | 2012-03-30

SECONDARY ACCESSION(S): GSE32378PRJNA147955

REPOSITORIES: GEO, ArrayExpress

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Publications

Identification of host genes linked with the survivability of chickens infected with recombinant viruses possessing H5N1 surface antigens from a highly pathogenic avian influenza virus.

Uchida Yuko Y   Watanabe Chiaki C   Takemae Nobuhiro N   Hayashi Tsuyoshi T   Oka Takehiko T   Ito Toshihiro T   Saito Takehiko T  

Journal of virology 20111221 5


Seventeen recombinant viruses were generated by a reverse genetic technique to elucidate the pathogenicity of highly pathogenic avian influenza viruses (HPAIVs) in chickens. The recombinant viruses generated possessed hemagglutinin (HA) and neuraminidase (NA) genes from an HPAIV. Other segments were combinations of the genes from an HPAIV and two low-pathogenic avian influenza viruses (LPAIVs) derived from chicken (LP) and wild bird (WB). Exchange of whole internal genes from an HPAIV with those  ...[more]

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