Transcriptomics

Dataset Information

4

A central role for TFIID in the pluripotent transcription circuitry


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Marian Groot Koerkamp  

PROVIDER: E-GEOD-33646 | ArrayExpress | 2013-03-21

SECONDARY ACCESSION(S): GSE33646PRJNA148651

REPOSITORIES: GEO, ArrayExpress

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Publications


Embryonic stem (ES) cells are pluripotent and characterized by open chromatin and high transcription levels, achieved through auto-regulatory and feed-forward transcription factor loops. ES-cell identity is maintained by a core of factors including Oct4 (also known as Pou5f1), Sox2, Klf4, c-Myc (OSKM) and Nanog, and forced expression of the OSKM factors can reprogram somatic cells into induced pluripotent stem cells (iPSCs) resembling ES cells. These gene-specific factors for RNA-polymerase-II-m  ...[more]

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