ORGANISM(S): Colinus virginianus
SUBMITTER: Kurt Gust Lynn Escalon Xin Guan Mark S Johnson Edward J Perkins Youping Deng Mehdi Pirooznia Kurt A Gust Joan Clarke Karl J Indest Ping Gong Michel J Quinn Jr.
REPOSITORIES: GEO, ArrayExpress
Toxicological sciences : an official journal of the Society of Toxicology 20090505 1
Munitions constituents (MCs) including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), and TNT derivatives are recognized to elicit aberrant neuromuscular responses in many species. The onset of seizures resulting in death was observed in the avian model Northern bobwhite after oral dosing with RDX beginning at 8 mg/kg/day in subacute (14 days) exposures, whereas affective doses of the TNT derivative, 2,6-dinitrotoluene (2,6-DNT), caused gastrointestinal impacts, leth ...[more]