Transcriptomics

Dataset Information

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Expression data from mouse kidney tissue


ABSTRACT: The role of the renin-angiotensin system in chronic kidney disease involves multiple peptides and receptors. Exerting antipodal pathophysiological mechanisms, renin inhibition and AT1 antagonism ameliorate renal damage. This is a comparison between the renin inhibitor aliskiren with the At1 antagonist losartan in mice with chronic kidney disease due to renal ablation. Renal tissue from ablated mice was used after 6-week treatment with either 500 mg/l losartan or 50 mg/kg aliskiren per day (n = 5)

ORGANISM(S): Mus musculus  

SUBMITTER: Thomas Streichert  Ulrich O Wenzel   Christoph Fraune    

PROVIDER: E-GEOD-34552 | ArrayExpress | 2012-11-05

SECONDARY ACCESSION(S): GSE34552PRJNA151539

REPOSITORIES: GEO, ArrayExpress

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The role of the renin-angiotensin system in chronic kidney disease involves multiple peptides and receptors. Exerting antipodal pathophysiological mechanisms, renin inhibition and AT(1) antagonism ameliorate renal damage. However, it is unclear which mechanism exerts better nephroprotection. We compared the renin inhibitor aliskiren with the AT(1) antagonist losartan in mice with chronic kidney disease due to renal ablation. Doses were adjusted to equipotent inhibition of the renin-angiotensin s  ...[more]

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