Transcriptomics

Dataset Information

120

Gene expression profile of Drosophila tumoral eye discs (ey-Gal4 GS(2)88A8 UAS-Dl)


ABSTRACT: Growth of the drosophila eye imaginal discs is controlled by the activation of Notch in the dorsal-ventral boundary. Overexpression in the eye disc of the Notch ligand Delta together with lola and pipsqueak from the GS(2)88A8 line induces tumoral growth. We used microarray to analyze the expression profile of tumoral discs. Antennal-eye discs of Drosophila L3 larvae were selected for RNA extraction and hybridization on Affymetrix microarrayas. Two genetic conditions were analyzed: tumoral eye discs (ey-Gal4 GS(2)88A8 UAS-Dl) and control eye discs (GS(2)88A8 UAS-Dl). Three different biological replicates of each condition, each one consisting on 300 hundred pairs of eye discs, were analyzed.

REANALYSED by: E-GEOD-35471

ORGANISM(S): Drosophila melanogaster  

SUBMITTER: Alisson Gontijo   Veronica Miguela  Esther Caparros  Maria Dominguez  andres garelli  Andres Garelli 

PROVIDER: E-GEOD-35471 | ArrayExpress | 2012-02-20

SECONDARY ACCESSION(S): GSE35471PRJNA152351

REPOSITORIES: GEO, ArrayExpress

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Publications

Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation.

Garelli Andres A   Gontijo Alisson M AM   Miguela Veronica V   Caparros Esther E   Dominguez Maria M  

Science (New York, N.Y.) 20120501 6081


Developing animals frequently adjust their growth programs and/or their maturation or metamorphosis to compensate for growth disturbances (such as injury or tumor) and ensure normal adult size. Such plasticity entails tissue and organ communication to preserve their proportions and symmetry. Here, we show that imaginal discs autonomously activate DILP8, a Drosophila insulin-like peptide, to communicate abnormal growth and postpone maturation. DILP8 delays metamorphosis by inhibiting ecdysone bio  ...[more]

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