Transcriptomics

Dataset Information

0

Polyphenols protection against fructose overload


ABSTRACT: To decipher the beneficial effects of Polyphenols on health, healthy volunteers were randomized into two groups and were submitted to either a red grape polyphenol rich extract supplemented diet (PP) or a placebo diet (PCB) during 8 weeks. Then they were submitted to a fructose load (3g/kg Fat Free Mass/day) during 7 days. Muscle biopsies were taken before the protocol, 8 weeks after PP or PCB diet and after the 7 days fructose load. We have employed whole genome microarray expression profiling as a discovery platform to identify genes regulated by fructose and to identify the mechanism of action of Polyphenols. Healthy volunteers were randomized into two groups and were submitted to either a red grape polyphenol rich extract supplemented diet (PP) or a placebo diet (PCB) during 8 weeks. Then they were submitted to a fructose load (3g/kg Fat Free Mass/day) during 7 days. Muscle biopsies were taken before the protocol, 8 weeks after PP or PCB diet and after the 7 days fructose load. We have employed whole genome microarray expression profiling as a discovery platform to identify genes regulated by fructose and to identify the mechanism of action of Polyphenols. Ten biological replicates were processed for PP diet, nine for PCB diet.

ORGANISM(S): Homo sapiens  

SUBMITTER: Antoine Avignon  Emilie Blond   Hubert Vidal   emmanuelle meugnier   Emmanuelle Meugnier   Sandra Pesenti    

PROVIDER: E-GEOD-35764 | ArrayExpress | 2013-02-04

SECONDARY ACCESSION(S): GSE35764PRJNA152107

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications


To assess the clinical efficacy of nutritional amounts of grape polyphenols (PPs) in counteracting the metabolic alterations of high-fructose diet, including oxidative stress and insulin resistance (IR), in healthy volunteers with high metabolic risk.Thirty-eight healthy overweight/obese first-degree relatives of type 2 diabetic patients (18 men and 20 women) were randomized in a double-blind controlled trial between a grape PP (2 g/day) and a placebo (PCB) group. Subjects were investigated at b  ...[more]

Similar Datasets

2014-02-01 | E-GEOD-52644 | ArrayExpress
2011-03-17 | GSE21417 | GEO
2015-07-31 | E-GEOD-52644 | ExpressionAtlas
2011-03-17 | E-GEOD-21417 | ArrayExpress
| PRJNA152107 | ENA
2007-11-13 | E-MEXP-934 | ArrayExpress
| GSE100846 | GEO
2012-10-18 | E-GEOD-41644 | ArrayExpress
2013-09-10 | E-MTAB-1530 | ArrayExpress
| PRJNA443284 | ENA