Genomics

Dataset Information

1

Expression data from melanoma subpopulations


ABSTRACT: We aimed at identifying lymphangiogenic subpopulations by comparative analysis of single cell clones derived from a melanoma of a single patient. Selected clones were grafted into SCID mice, where they induced lymphangiogenesis and metastasized into sentinel nodes, whereas non-lymphangiogenic clones from the same patient did not metastasize. RNA isolated from primary SCID mouse tumors were used for transcriptome analysis. A total of 16 Samples were analysed, 4 per group. Parental pool MCM1(C), nonlymphangiogenic MCM1G(G), lymphangiogenic MCM1D(D1), lymphangiogenic and very metastatic MCM1DLN(D2).

REANALYSED by: E-GEOD-36035

ORGANISM(S): Homo sapiens  

DISEASE(S): Nodular Melanoma

SUBMITTER: Mario Mikula   Peter Petzelbauer 

PROVIDER: E-GEOD-36035 | ArrayExpress | 2012-06-17

SECONDARY ACCESSION(S): GSE36035PRJNA151755

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-36035.idf.txt Idf
E-GEOD-36035.processed.1.zip Processed
E-GEOD-36035.raw.1.zip Raw
E-GEOD-36035.sdrf.txt Txt
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Publications

MET expression in melanoma correlates with a lymphangiogenic phenotype.

Swoboda Alexander A   Schanab Oliver O   Tauber Stefanie S   Bilban Martin M   Berger Walter W   Petzelbauer Peter P   Mikula Mario M  

Human molecular genetics 20120507 15


Melanomas contain high frequencies of tumorigenic cells and their tumorigenic capacity resides in several distinct subpopulations within melanoma. Since their metastatic potential is linked to their ability to recruit lymphatic vessels, we aimed at identifying lymphangiogenic subpopulations by comparative in vitro analysis of single cell clones derived from a melanoma of a single patient. Selected lymphangiogenic clones were then grafted into severe combined immunodeficient mice, where they indu  ...[more]

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