Transcriptomics

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Pulmonary miRNA expression in C57BL/6 Bom Tac mice (dams) intratracheally instilled with Printex 90 carbon black nanoparticles


ABSTRACT: miRNAs were measured in pregant mice exposed to vehicle control (nanopure water) or a cumulative dose of 0.268 mg Printex 90 in vehicle by intratracheal instillation and sacrificed at weaning (26-27 days after exposure). Pregnant mice were exposed to vehicle control (nanopure water) or a cumulative dose of 0.268 mg Printex 90 in vehicle by intratracheal instillation. Doses of 0.067 mg were delivered 4 times in pregnant females on gestational days 7, 10, 15 and 18. Mice were sacrificed at weaning (26-27 days post-exposure).

ORGANISM(S): Mus musculus  

SUBMITTER: Dongmei Wu  Julie A Bourdon   Anne T Saber   Sabina Halappanavar   Petra A Jackson   Håkan Wallin   Karin Hougaard   Andrew Williams   Nicklas R Jacobsen   Carole L Yauk   Ulla B Vogel    

PROVIDER: E-GEOD-36170 | ArrayExpress | 2012-04-01

SECONDARY ACCESSION(S): GSE36170PRJNA155777

REPOSITORIES: GEO, ArrayExpress

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Publications

Hepatic and pulmonary toxicogenomic profiles in mice intratracheally instilled with carbon black nanoparticles reveal pulmonary inflammation, acute phase response, and alterations in lipid homeostasis.

Bourdon Julie A JA   Halappanavar Sabina S   Saber Anne T AT   Jacobsen Nicklas R NR   Williams Andrew A   Wallin Håkan H   Vogel Ulla U   Yauk Carole L CL  

Toxicological sciences : an official journal of the Society of Toxicology 20120329 2


Global pulmonary and hepatic messenger RNA profiles in adult female C57BL/6 mice intratracheally instilled with carbon black nanoparticles (NPs) (Printex 90) were analyzed to identify biological perturbations underlying systemic responses to NP exposure. Tissue gene expression changes were profiled 1, 3, and 28 days following exposure to 0.018, 0.054, and 0.162 mg Printex 90 alongside controls. Pulmonary response was marked by increased expression of inflammatory markers and acute phase response  ...[more]

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