Dataset Information


The microRNA expression profile of C2C12 cell upon 72 hours of BMP2 treatment

ABSTRACT: To identify osteoblast specific miRNAs that can contribute to osteoblastogenesis by post-transcriptionally regulates their targets, BMP2 are treated to C2C12 for 72 hours and performed miRNA microarray. C2C12 cells were treated with vehicles or BMP2 (300 ng/mL) supplemented alpha-MEM media for 72 days and total RNA was harvested and performed exiqon miRNA microarray. Duplicates were used for each condition. Dye swaps were done.

ORGANISM(S): Mus musculus  

SUBMITTER: Brian Dawson   Yangjin Bae 

PROVIDER: E-GEOD-37036 | ArrayExpress | 2012-05-02



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miRNA-34c regulates Notch signaling during bone development.

Bae Yangjin Y   Yang Tao T   Zeng Huan-Chang HC   Campeau Philippe M PM   Chen Yuqing Y   Bertin Terry T   Dawson Brian C BC   Munivez Elda E   Tao Jianning J   Lee Brendan H BH  

Human molecular genetics 20120412 13

During bone homeostasis, osteoblast and osteoclast differentiation is coupled and regulated by multiple signaling pathways and their downstream transcription factors. Here, we show that microRNA 34 (miR-34) is significantly induced by BMP2 during osteoblast differentiation. In vivo, osteoblast-specific gain of miR-34c in mice leads to an age-dependent osteoporosis due to the defective mineralization and proliferation of osteoblasts and increased osteoclastogenesis. In osteoblasts, miR-34c target  ...[more]

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