Transcriptomics

Dataset Information

0

Changes in mammary gene expression and morphology following consumption of soy protein isolate in female Sprague-Dawley rats differs from that produced by 17b-estradiol treatment


ABSTRACT: Soy foods have been suggested to have both positive health benefits and potentially adverse effects largely as a result of their content of isoflavone phytoestrogens. Since soy protein isolate (SPI) contains isoflavones, in addition to purported health benefits, safety concerns have been raised regarding the use of SPI and soy formulas, because of potential estrogenic actions during the neonatal period, including the potential for reproductive toxicity, infertility, and the possibility of increased risk for development and recurrence of estrogen sensitive cancers such as breast cancer. In the current study, we used a rat model to compare the effects of SPI with those of 17b-estradiol (E2), on global gene expression profiles and morphology in the female rat mammary gland. Rats were either fed AIN-93G diets containing casein (CAS) or SPI beginning on postnatal day (PND) 30. Rats were ovariectomized (OVX) on PND 50 and treated with E2 or vehicle for 14 days. Microarray analysis was carried out to compare the effects of SPI and E2 alone or in combination on the mammary gene expression. The data suggest a non-estrogenic effect of SPI on the rat mammary even in the absence of endogenous estrogens.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Horacio Gomez-Acevedo  Martin J Ronis   Rohit Singhal   Kartik Shankar   Leah Hennings   Thomas M Badger   Michael L Blackburn    

PROVIDER: E-GEOD-38060 | ArrayExpress | 2012-05-21

SECONDARY ACCESSION(S): GSE38060PRJNA167294

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets

2015-06-13 | E-GEOD-69819 | ArrayExpress
2012-07-14 | E-GEOD-30862 | ArrayExpress
2015-09-17 | E-GEOD-30862 | ExpressionAtlas
2012-09-10 | E-GEOD-40713 | ArrayExpress
2009-07-23 | GSE12217 | GEO
2007-11-29 | E-GEOD-6879 | ArrayExpress
2009-08-07 | E-GEOD-12217 | ArrayExpress
2010-09-25 | E-GEOD-21150 | ArrayExpress
2015-09-30 | E-GEOD-40713 | ExpressionAtlas
2014-06-30 | E-GEOD-37849 | ArrayExpress