Transcriptomics

Dataset Information

3

Expression data from primary human mammary fibroblasts purified from disease-free women of low and high mammographic density


ABSTRACT: Although high mammographic density (MD) is considered one of the strongest risk factors for invasive breast cancer, the genes involved in modulating this clinical feature are unknown. Histologically, areas of high MD are associated with low adipocyte content and high matrix content, both stromal phenotypes. We hypothesized that fibroblasts purified from low and high MD tissues would show gene expression differences responsible for these histologic differences. Fibroblasts were purified from disease-free breast tissue from 6 women with low MD (MD quartile 2) and 7 women with high MD (MD quartile 4). The fibroblasts were cultured for 3 to 6 passages before cells pellets were collected for this study.

ORGANISM(S): Homo sapiens  

SUBMITTER: Thea D Tlsty   RosaAnna DeFilippis 

PROVIDER: E-GEOD-38506 | ArrayExpress | 2012-06-05

SECONDARY ACCESSION(S): GSE38506PRJNA168091

REPOSITORIES: GEO, ArrayExpress

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Publications


Although high mammographic density is considered one of the strongest risk factors for invasive breast cancer, the genes involved in modulating this clinical feature are unknown. Tissues of high mammographic density share key histologic features with stromal components within malignant lesions of tumor tissues, specifically low adipocyte and high extracellular matrix (ECM) content. We show that CD36, a transmembrane receptor that coordinately modulates multiple protumorigenic phenotypes, includi  ...[more]

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