Dataset Information


Influence of G0s2 gene knockdown on primary hepatocyte

ABSTRACT: Hepatocellular carcinoma is the third leading cause of cancer death worldwide, and it is necessary to elucidate the mechanism of hepatocarcinogenesis. Circadian clock systems have been related in cell cycle and carcinogenesis. In this study, hepatocarcinogenesis induced by DEN administration in mice was inhibited by knockdown of G0s2 at early stage in carcinogenesis. In addition, the circadian expression of G0s2 in mouse liver was regulated by RARα controlled by clock genes and ATRA. Moreover, mice administered both ATRA and DEN were not induced hepatocellular carcinoma, and decreased the expression of G0s2 at second day after the initiation of administration. These findings suggest that the control of G0s2 expression is important in carcinogenesis and G0s2 might be the novel target for prevention, diagnosis and treatment of hepatocellular carcinoma. Differential gene expression between G0s2 siRNA or Control siRNA transfected primary hepatocyte was measured after 24 hr of transfection.

ORGANISM(S): Mus musculus  

SUBMITTER: Keisuke Kakimoto   naoya matsunaga  Kaori Yasuda  Atsushi Doi  Shigehiro Ohdo  Satoru Koyanagi  Naoya Matsunaga 

PROVIDER: E-GEOD-39288 | ArrayExpress | 2013-08-01



Similar Datasets

2014-06-06 | E-GEOD-57798 | ArrayExpress
2008-08-09 | GSE8747 | GEO
2015-05-05 | E-GEOD-59260 | ArrayExpress
2015-05-05 | E-GEOD-59259 | ArrayExpress
| GSE89689 | GEO
2013-09-27 | E-GEOD-51188 | ArrayExpress
2014-02-28 | E-GEOD-27638 | ArrayExpress
2008-08-09 | E-GEOD-8747 | ArrayExpress
2013-04-27 | E-GEOD-46408 | ArrayExpress
| GSE23375 | GEO