Transcriptomics,Genomics

Dataset Information

66

FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Olli A. Jänne  

PROVIDER: E-GEOD-39880 | ArrayExpress | 2013-02-05

SECONDARY ACCESSION(S): GSE39880PRJNA171945

REPOSITORIES: GEO, ArrayExpress

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Publications

FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells.

Sahu Biswajyoti B   Laakso Marko M   Pihlajamaa Päivi P   Ovaska Kristian K   Sinielnikov Ievgenii I   Hautaniemi Sampsa S   Jänne Olli A OA  

Cancer research 20121226 5


The forkhead protein FoxA1 has functions other than a pioneer factor, in that its depletion brings about a significant redistribution in the androgen receptor (AR) and glucocorticoid receptor (GR) cistromes. In this study, we found a novel function for FoxA1 in defining the cell-type specificity of AR- and GR-binding events in a distinct fashion, namely, for AR in LNCaP-1F5 cells and for GR in VCaP cells. We also found different, cell-type and receptor-specific compilations of cis-elements enric  ...[more]

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