Transcriptomics

Dataset Information

4

The effect on gene expression of Smchd1 deletion in primary MEFs, transformed MEFs and MEF tumours


ABSTRACT: Smchd1 appears to act as a tumour suppressor in the transformed fibroblast model. We find gene expression differences are most pronounced in the transformed MEFs. We always detect a small number of clustered genes and imprinted genes as differentially expressed, along with others involved in tumorigenesis. The microarrays compared Smchd1 null and Smchd1 wildtype samples from different cell types (primary MEFs, transformed MEFs, tumours derived from transformed MEFs). Wildtype mice are FVB/N and Smchd1 null mice have the MommeD1 point mutation on a FBV/N background.

ORGANISM(S): Mus musculus  

SUBMITTER: Marnie E Blewitt   Huei S Leong  Gordon K Smyth  Yifang Hu 

PROVIDER: E-GEOD-40734 | ArrayExpress | 2012-09-30

SECONDARY ACCESSION(S): GSE40734PRJNA174772

REPOSITORIES: GEO, ArrayExpress

Similar Datasets

2012-09-30 | E-GEOD-40992 | ArrayExpress
| GSE121184 | GEO
2012-09-30 | E-GEOD-40881 | ArrayExpress
2012-09-30 | E-GEOD-40880 | ArrayExpress
2012-09-30 | E-GEOD-40879 | ArrayExpress
| GSE121087 | GEO
| GSE122019 | GEO
2008-06-14 | E-GEOD-6206 | ArrayExpress
| GSE122196 | GEO
| GSE122094 | GEO