Transcriptomics,Genomics

Dataset Information

299

Allele-specific Methylation of Human Placental Tissue


ABSTRACT: In this study, we screened human placental samples for allele-specific methylation and subsequently novel imprinted genes associated with these regions. We used reduced representation bisulfite sequencing to identify partially methylated CpG islands (CGIs) in the human placental genome. We were able to delineate potential candidates for allele-specific methylation based on the calculation of a concordance statistic. Amongst the 28 regions chosen for validation based on high levels of expression, two regions were shown to exhibit allele-specific expression. Single base-resolution methylation analysis in the placental genome and RNA-Seq

ORGANISM(S): Homo sapiens  

SUBMITTER: Chunming Ding  

PROVIDER: E-GEOD-40955 | ArrayExpress | 2013-10-09

SECONDARY ACCESSION(S): SRP015789GSE40955PRJNA175668

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

DNMT1 and AIM1 Imprinting in human placenta revealed through a genome-wide screen for allele-specific DNA methylation.

Das Radhika R   Lee Yew Kok YK   Strogantsev Ruslan R   Jin Shengnan S   Lim Yen Ching YC   Ng Poh Yong PY   Lin Xueqin Michelle XM   Chng Keefe K   Yeo George Sh GSh   Ferguson-Smith Anne C AC   Ding Chunming C  

BMC genomics 20131005


Genomic imprinting is an epigenetically regulated process wherein genes are expressed in a parent-of-origin specific manner. Many imprinted genes were initially identified in mice; some of these were subsequently shown not to be imprinted in humans. Such discrepancy reflects developmental, morphological and physiological differences between mouse and human tissues. This is particularly relevant for the placenta. Study of genomic imprinting thus needs to be carried out in a species and developmen  ...[more]

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