Transcriptomics

Dataset Information

3

Gene expression analysis after selective expression of tissue factor isoforms


ABSTRACT: Analysis of TF isoform-induced breast cancer cell transformation at gene expression level. The hypothesis tested in the present study was that expression of TF isoforms upregulate genes involved in proliferation and transformation, while downregulating genes involved in cell cycle arrest and apoptosis. Results provide important information on the cellular response to TF expression with respect to pro-oncogenic programs . Total RNA obtained from an MCF-7-based cell model (2A3-3) expressing full length tissue factor (2A3-3-flTF) or alternatvively spliced tissue factor (2A3-3-asTF) compared to cells expressing an empty vector control (2A3-3-pcDNA).

ORGANISM(S): Homo sapiens  

SUBMITTER: Henri H Versteeg   Henri Versteeg  Begüm Kocatürk 

PROVIDER: E-GEOD-41872 | ArrayExpress | 2012-10-27

SECONDARY ACCESSION(S): GSE41872PRJNA178362

REPOSITORIES: GEO, ArrayExpress

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